دانلود The Logic of Chemical Synthesis کتاب منطق سنتز های شیمیایی کوری و چنگ

دانلود The Logic of Chemical Synthesis کتاب منطق سنتز های شیمیایی کوری و چنگ 

کتاب منطق سنتز های شیمایی ترکیب های آلی نوشته کوری و چنگ The Logic of Chemical Synthesis by E. J. Corey, Xue-Min Cheng از بهترین کتاب های مرجع شیمی آلی در زمینه مکانیسم و روش انجام واکنش های شیمی آلی و سنتز ترکیب های آن می باشد.

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مشخصات کتاب 

• عنوان کتاب: The Logic of Chemical Synthesis
• فرمت فایل: PDF و با کیفیت بالا
• حجم فایل فشرده: 4.53 مگابایت
• زبان نوشتاری: انگلیسی
• ویرایش: 1
• شابک: 9780471115946, 0471115940
• نویسنده:   E. J. Corey, Xue-Min Cheng       
• تعداد صفحات: 462 صفحه 
• تعداد فصل ها: 13 فصل
• نحوه دریافت : دانلود فوری و آنی فایل بعد از پرداخت

فهرست مطالب فصل های کتاب

CONTENTS OF PART ONE
GENERAL APPROACHES TO THE ANALYSIS OF COMPLEX SYNTHETIC PROBLEMS
CHAPTER ONE
The Basis for Retrosynthetic Analysis
1.1 Multistep Chemical Synthesis
1.2 Molecular Complexity
1.3 Thinking About Synthesis
1.4 Retrosynthetic Analysis
1.5 Transforms and Retrons
1.6 Types of Transforms
1.7 Selecting Transforms
1.8 Types of Strategies for Retrosynthetic Analyses
CHAPTER TWO
Transform-Based Strategies
2.1 Transform-Guided Retrosynthetic Search
2.2 Diels-Alder Cycloaddition as a T-Goal
2.3 Retrosynthetic Analysis of Fumagillol
2.4 Retrosynthetic Analysis of Ibogamine
2.5 Retrosynthetic Analysis of Estrone
2.6 Retrosynthetic Analysis by Computer Under T-Goal Guidance
2.7 Retrosynthetic Analysis of Squalene
2.8 Enantioselective Transforms as T-Goals
2.9 Mechanistic Transform Application
2.10 T-Goal Search Using Tactical Combinations of Transforms
CHAPTER THREE
Structure-Based and Topological Strategies
3.1 Structure-goal (S-goal) Strategies
3.2 Topological Strategies
3.3 Acyclic Strategic Disconnections
3.4 Ring-Bond Disconnections-Isolated Rings
3.5 Disconnection of Fused-Ring Systems
3.6 Disconnection of Bridged-Ring Systems
3.7 Disconnection of Spiro Systems
3.8 Application of Rearrangement Transforms as a Topological Strategy
3.9 Symmetry and Strategic Disconnections
CHARTER FOUR
Stereochemical Strategies
4.1 Stereochemical SimplificationTransform Stereoselectivity
4.2 Stereochemical ComplexityClearable Stereocenters
4.3 Stereochemical StrategiesPolycyclic Systems
4.4 Stereochemical StrategiesAcyclic Systems
CHAPTER FIVE
Functional Group-Based and Other Strategies
5.1 Functional Groups as Elements of Complexity and Strategy
5.2 Functional Group-Keyed Skeletal Disconnections
5.3 Disconnection Using Tactical Sets of Functional Group-Keyed Transforms
5.4 Strategic Use of Functional Group Equivalents
5.5 Acyclic Core Group Equivalents of Cyclic Functional Groups
5.6 Functional Group-Keyed Removal of Functionally and Stereocenters
5.7 Functional Groups and Appendages as Keys for Connective Transforms
5.8 Functional Group-Keyed Appendage Disconnection
5.9 Strategies External to the Target Structure
5.10 Optimization of a Synthetic Sequence
CHAPTER SIX
Concurrent Use of Several Strategies
6.1 Multistrategic Retrosynthetic Analysis of Longifolene
6.2 Multistrategic Retrosynthetic Analysis of Porantherine
6.3 Multistrategic Retrosynthetic Analysis of Perhydrohistrionicotoxin
6.4 Multistrategic Retrosynthetic Analysis of Gibberellic Acid
6.5 Multistrategic Retrosynthetic Analysis of Picrotoxinin
6.6 Multistrategic Retrosynthetic Analysis of Retigeranic Acid
6.7 Multistrategic Retrosynthetic Analysis of Ginkgolide B
References
Glossary of Terms
CONTENTS OF PART TWO
SPECIFIC PATHWAYS FOR THE SYNTHESIS OF COMPLEX MOLECULES Introduction Abbreviations
CHAPTER SEVEN
Macrocyclic Structures
7.1 Erythronolide B
7.2 Erythronolide A
7.3 Recifeiolide
7.4 Vermiculine
7.5 Enterobactin
7.6 N-Methylmaysenine
7.7 (-)-N-Methylmaysenine
7.8 Maytansine
7.9 Brefeldin A
7.10 Aplasmomycin
CHAPTER EIGHT
Heterocyclic Structures
8.1 Perhydrohistrionicotoxin
8.2 Porantherine
8.3 Biotin
8.4 Methoxatin
8.5 20-(S)-Camptothecin
CHAPTER NINE
Sesquiterpenoids
9.1 Insect Juvenile Hormones and Farnesol
9.2 Longifolene
9.3 Caryophyllenes
9.4 Caryophyllene Alcohol
9.5 Cedrene and Cedrol
9.6 Humulene
9.7 Dihydrocostunolide
9.8 Elemol
9.9 Helminthosporal
9.10 Sirenin
9.11 Sesquicarene
9.12 Copaene and Ylangene
9.13 Occidentalol
9.14 Bergamotene
9.15 Fumagillin
9.16 Ovalicin
9.17 Picrotoxinin and Picrotin
9.18 Isocyanopupukeananes
9.19 Bisabolenes
CHAPTER TEN
Polycyclic Isoprenoids
10.1 Aphidicolin
10.2 Stemodinone and Stemodin
10.3 K-76
10.4 Tricyclohexaprenol
10.5 Atractyligenin
10.6 Cafestol
10.7 Kahweol
10.8 Gibberellic Acid
10.9 Antheridic Acid
10.10 Retigeranic Acid
10.11 Diisocyanoadociane
10.12 Ginkgolide B and Ginkgolide A
10.13 Bilobalide
10.14 Forskolin
10.15 Venustatriol
10.16 Pseudopterosin A
10.17 α-Amyrin
10.18 β-Amyrin
10.19 Pentacyclosqualene
10.20 Dihydroconessine
CHAPTER ELEVEN
Prostanoids
11.1 Structures of Prostaglandins (PG’s)
11.2 (±)-Prostaglandins E1, F1α, F1β, A1 and B1
11.3 Prostaglandins E1, F1α and Their 11-Epimers
11.4 General Synthesis of Prostaglandins
11.5 Refinements of the General Synthesis of Prostaglandins
11.6 Prostaglandins E3 and F3α
11.7 Modified Bicyclo[2.2.1]heptane Routes to Prostaglandins
11.8 Synthesis of Prostaglandin A2 and Conversion to Other Prostaglandins
11.9 Alternative Synthesis of Prostaglandins F1α and E1
11.10 Conjugate Addition-Alkylation Route to Prostaglandins
11.11 Bicyclo[3.1.0]hexane Routes to Prostaglandins
11.12 Prostaglandin F2α from a 2-Oxabicyclo[3.3.0]octenone
11.13 11-Desoxyprostaglandins
11.14 Prostacycline (PGI2)
11.15 Major Human Urinary Metabolite of Prostaglandin D2
11.16 Analogs of the Prostaglandin Endoperoxide PGH2
11.17 12-Methylprostaglandin A2 and 8-Methylprostaglandin C2
11.18 Synthesis of Two Stable Analogs of Thromboxane A2
11.19 Synthesis of (±)-Thromboxane B2
11.20 Synthesis of Prostaglandins via an Endoperoxide Intermediate. Stereochemical
Divergence of Enzymatic and Biomimetic Chemical Cyclization Reactions
11.21 (±)-Clavulone I and (±)-Clavulone II
11.22 (-)-Preclavulone-A
11.23 Hybridalactone
CHAPTER TWELVE
Leukotrienes and Other Bioactive Polyenes
12.1 Formation of Leukotrienes from Arachidonic Acid
12.2 Leukotriene A4
12.3 Leukotriene C4 and Leukotriene D4
12.4 Leukotriene B4
12.5 Synthesis of Stereoisomers of Leukotriene B4
12.6 Leukotriene B5
12.7 5-Desoxyleukotriene D4
12.8 Synthesis of the 11,12-Oxido and 14,15-Oxido Analogs of Leukotriene A4 and the Corresponding Analogs of Leukotriene C4 and Leukotriene D4
12.9 12-Hydroxy-5,8,14-(Z)-10-(E)-eicosatetraenoic Acid (12-HETE)
12.10 Hepoxylins and Related Metabolites of Arachidonic Acid
12.11 Synthesis of 5-, 11-, and 15-HETE’s. Conversion of HETE’s into the
Corresponding HPETE’s
12.12 Selective Epoxidation of Arachidonic Acid
12.13 Synthesis of Irreversible Inhibitors of Eicosanoid Biosynthesis, 5,6-, 8,9-, and 11,12-Dehydroarachidonic Acid
12.14 Synthesis of a Class of Sulfur-Containing Lipoxygenase Inhibitors
12.15 Synthesis of a Putative Precursor of the Lipoxins
12.16 Bongkrekic Acid
CONTENTS OF PART THREE
GUIDE TO THE ORIGINAL LITERATURE OF MULTISTEP SYNTHESIS
CHAPTER THIRTEEN
13.1 Introduction
13.2 Abbreviations of Journal Names
13.3 Acyclic and Monocarbocyclic Structures
13.4 Fused-Ring Bi- and Tricarbocyclic Structures
13.5 Bridged-Ring Carbocyclic Structures
13.6 Higher Terpenoids and Steroids
13.7 Nitrogen Heterocycles (Non-bridged, Non-indole)
13.8 Fused-Ring Indole Alkaloids
13.9 Bridged-Ring Indole Alkaloids
13.10 Bridged-Ring Non-Indole Alkaloids; Porphrins
13.11 Polycyclic Benzenoid Structures
13.12 Oxygen Heterocycles
13.13 Macrocylic Lactones
13.14 Macrocylic Lactams
13.15 Polyethers
Index