Modern Organic Synthesis 1st Edition George S. Zweifel کتاب سنتز آلی مدرن ویرایش 1

Modern Organic Synthesis 1st Edition George S. Zweifel کتاب سنتز آلی مدرن ویرایش 1

کتاب سنتز آلی مدرن ویرایش 1 اول Modern Organic Synthesis 1st Edition تالیف و نوشته George S. Zweifel , Michael H. Nantz از کتاب های تخصصی شیمی آلی که به بررسی و ارائه انواع روش و متدهای سنتز آلی مدرن پرداخته است . این کتاب توسط انتشارات Freeman به چاپ رسیده است و یکی از کتاب های پر طرفدار در زمینه سنتز آلی در بین دانشجویان و اساتید شیمی به حساب می آید.

 

مشخصات کتاب

• عنوان انگلیسی:  Modern Organic Synthesis
• عنوان فارسی : سنتز آلی مدرن
• فرمت فایل: PDF
• حجم فایل فشرده:  24 مگابایت 
• ویرایش: 1
• سال انتشار: March 17, 2007
• زبان نوشتاری: انگلیسی
• نویسنده(ها):  George S. Zweifel | Michael H. Nantz
• تعداد صفحات: 486 صفحه
• تعداد فصل ها: 9 فصل
• نحوه دریافت : دریافت فوری و آنی لینک دانلود فایل بعد از پرداخت

 

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فهرست مطالب و عناوین فصل های کتاب

 

Synthetic Design

1.1 Retrosynthetic Analysis

1.2 Reversal of the Carbonyl Group Polarity (Umpolung)

1.3 Steps in Planning a Synthesis

1.4 Choice of SyntheticMethod

1.5 Domino Reactions (Cascade or Tandem Reactions)

1.6 Computer-Assisted Retrosynthetic Analysis

References

Stereochemical Considerations in Planning Syntheses

2.1 Conformational Analysis

2.2 Evaluation of Non-Bonded Interactions

2.3 Six-Membered Heterocyclic Systems

2.4 Polycyclic Ring Systems

2.5 Cyclohexyl Systems with sp2-Hybridized Atoms

2.6 Significant Energy Difference

2.7 Computer-Assisted Molecular Modeling

2.8 Reactivity and Product Determination as a Function of Conformation

References

The Concept of Protecting Functional Groups

3.1 Protection of N–H Groups

3.2 Protection of OH Groups

3.3 Protection of Diols as Acetals

3.4 Protection of Carbonyl Groups in Aldehydes and Ketones

3.5 Protection of the Carboxyl Group

3.6 Protection of Double Bonds

3.7 Protection of Triple Bonds

References

Functional Group Transformations

4.1 Oxidation of Alcohols to Aldehydes and Ketones

4.2 Reagents and Procedures for Alcohol Oxidation

4.3 Chemoselective Oxidizing Agents

4.4 Oxidation of Acyloins

4.5 Oxidation of Tertiary Allylic Alcohols

4.6 Oxidative Procedures to Carboxylic Acids

4.7 Allylic Oxidation of Alkenes

4.8 Terminology for Reduction of Carbonyl Compounds

4.9 Nucleophilic Reducing Agents

4.10 Electrophilic Reducing Agents

4.11 Regio- and Chemoselective Reductions

4.12 Diastereoselective Reductions of Cyclic Ketones

4.13 Inversion of Secondary Alcohol Stereochemistry

4.14 Diastereofacial Selectivity in Acyclic Systems

4.15 Enantioselective Reductions

References

Functional Group Transformations

5.1 Reactions of Carbon–Carbon Double Bonds

5.2 Reactions of Carbon–Carbon Triple Bonds

References

Formation of Carbon–Carbon Single Bonds via Enolate Anions

6.1 1,3-Dicarbonyl Compounds

6.2 Direct Alkylation of Enolates

6.3 Cyclization Reactions—Baldwin’s Rules for Ring Closure

6.4 Stereochemistry of Cyclic Ketone Alkylation

6.5 Imine and Hydrazone Anions

6.6 Enamines

6.7 The Aldol Reaction

6.8 Condensation Reactions of Enols and Enolates

6.9 Robinson Annulation

References

Formation of Carbon–Carbon Bonds via Organometallic Reagents

7.1 Organolithium Reagents

7.2 Organomagnesium Reagents

7.3 Organotitanium Reagents

7.4 Organocerium Reagents

7.5 Organocopper Reagents

7.6 Organochromium Reagents

7.7 Organozinc Reagents

7.8 Organoboron Reagents

7.9 Organosilicon Reagents

7.10 Organogold Chemistry

References

Palladium-Catalyzed Coupling Reactions

8.1 Palladium Oxidation State

8.2 Organic Synthesis with Palladium(0) Complexes

8.3 The Heck Reaction—Palladium(0)-Catalyzed Olefin Insertion Reactions

8.4 Palladium-Catalyzed Cross-Coupling with Organometallic Reagents

8.5 Cross-Coupling Reactions Involving sp-Carbons

8.6 The Trost–Tsuji Reaction

References

Formation of Carbon–Carbon ��-Bonds

9.1 Formation of Carbon–Carbon Double Bonds

9.2 Formation of Carbon–Carbon Triple Bonds

References

The Art of Synthesis